CARVYKTI® is a BCMA-directed CAR-T CELL therapy
CARVYKTI® is an autologous immunotherapy in which a patient’s T cells are genetically modified to encode a chimeric antigen receptor (CAR) to find and destroy B-cell maturation antigen (BCMA)–expressing cells. BCMA is overexpressed on the surface of malignant multiple myeloma B-lineage cells; it is also expressed on the surface of late-stage B cells and plasma cells.
CAR-T With 2 BCMA-Targeting Single-Domain Antibodies
CAR-T=chimeric antigen receptor-T cell.
Correlation of the mechanism of action with clinical effect has not been established.
Manufacturing CARVYKTI® CAR-T cells
At the manufacturing site, the patient’s T cells are isolated and genetically modified to express the CARVYKTI® CAR.
ISOLATION
The patient's collected cells are cryopreserved and shipped from the leukapheresis center to the manufacturing site. After thawing, the T cells are isolated
MODIFICATION
The patient’s T cells are then genetically reprogrammed to express a CAR that targets BCMA with 2 distinct binding domains*
EXPANSION
These anti-BCMA CARVYKTI® CAR-T cells are then expanded in cell culture, washed, put into a suspension, checked for quality control, and cryopreserved for transport to the Certified Treatment Center
BCMA=B-cell maturation antigen; CAR=chimeric antigen receptor; CAR-T=chimeric antigen receptor-T cell.
*Correlation of the mechanism of action with clinical effect has not been established.
Learn More About CARVYKTI®
Treatment Process